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Registros recuperados : 6 | |
1. | | PINHEIRO JUNIOR, C. R.; PEREIRA, M. G.; AZEVEDO, A. C. de; HUYSSTEEN, C. van; ANJOS, L. H. C. dos; FONTANA, A.; SILVA NETO, E. C. da; VIEIRA, J. N.; SANTOS, T. G. Genesis and classification of carbonate soils in the State of Rio de Janeiro, Brazil. Journal of South American Earth Sciences, v. 108, 103183, Jun. 2021. Biblioteca(s): Embrapa Solos. |
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2. | | VIEIRA, J. N.; PINHEIRO, H. S. K.; BUENO, M. M.; CARVALHO JUNIOR, W. de; PEREIRA, N. R.; CARVALHO, D. C. de; SOARES, P. F. C. Priority areas for water resources conservation: study case Canal Guandu watershed. Aquatic Science and Technology, v. 9, n. 1, p. 1-17, Jan. 2021. Biblioteca(s): Embrapa Solos. |
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3. | | OLIVEIRA FILHO, J. de S.; VIEIRA, J. N.; SILVA, E. M. R. da; OLIVEIRA, J. G. B.; PEREIRA, M. G.; BRASILEIRO, F. G. Assessing the effects of 17 years of grazing exclusion in degraded semi-arid soils: evaluation of soil fertility, nutrients pools and stoichiometry. Journal of Arid Environments, v. 166, p. 1-10, 2019. Biblioteca(s): Embrapa Agrobiologia. |
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4. | | ABREU, F. R. e; VIEIRA, J. N. de S.; RAMOS, S. Y. Programa Nacional para a Produção e Uso do Biodiesel: diretrizes, desafios e perspectivas. Revista de Política Agrícola, Brasília, DF, ano 15, n. 3, p. 5-18, jul./set. 2006. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Algodão; Embrapa Semiárido; Embrapa Tabuleiros Costeiros; Embrapa Unidades Centrais. |
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5. | | SANTOS, A. C. dos; BRESSAN FILHO, A.; GAZZONI, D.; CONTINI, E.; ABREU, F. R. e; VIEIRA, J. N. de S.; RAMALHO, J.; MAGALHÃES, L. J. d'A. Plano Nacional de Agroenergia 2006-2011. Brasília, DF: Embrapa, 2005. 118 p. Biblioteca(s): Embrapa Amazônia Ocidental; Embrapa Pantanal; Embrapa Soja. |
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Registros recuperados : 6 | |
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Registro Completo
Biblioteca(s): |
Embrapa Suínos e Aves. |
Data corrente: |
03/08/2021 |
Data da última atualização: |
03/08/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
FERNANDES, A. C.; SILVA, V. H. da; GOES, C. P.; MOREIRA, G. C. M.; GODOY, T. F.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; LEDUR, M. C.; REZENDE, F. M. de; COUTINHO, L. L. |
Afiliação: |
ANNA CAROLINA FERNANDES, ESALQ; VINICIUS HENRIQUE DA SILVA, ESALQ; CAROLINA PURCELL GOES, ESALQ; GABRIEL COSTA MONTEIRO MOREIRA, University of Liège; THAIS FERNANDA GODOY, ESALQ; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA; FERNANDA MARCONDES REZENDE, University of Florida; LUIZ LEHMANN COUTINHO, ESALQ. |
Título: |
Genome-wide detection of CNVs and their association with performance traits in broilers. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
BMC Genomics, v. 22, n. 354, 2021. |
DOI: |
https://doi.org/10.1186/s12864-021-07676-1 |
Idioma: |
Inglês |
Conteúdo: |
Abstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular processes regulation and potassium channels. Conclusions: Overall, this CNV-based GWAS study unravels potential candidate genes that may regulate performance traits in chickens. Our findings provide a foundation for future functional studies on the role of specific genes in regulating performance in chickens. Keywords: GWAS, Performance, CNVs, QTLs, qPCR MenosAbstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular p... Mostrar Tudo |
Palavras-Chave: |
CNVs; Copy number variations; Desempenho zootécnico; GWAS; QPCR; QTLs. |
Thesagro: |
Gallus Domesticus; Genética Animal; Performance. |
Thesaurus NAL: |
Animal genetics; Animal performance; Gallus gallus; Genome-wide association study; Quantitative polymerase chain reaction; Quantitative trait loci. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/224781/1/final9547.pdf
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Marc: |
LEADER 03101naa a2200433 a 4500 001 2133197 005 2021-08-03 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12864-021-07676-1$2DOI 100 1 $aFERNANDES, A. C. 245 $aGenome-wide detection of CNVs and their association with performance traits in broilers.$h[electronic resource] 260 $c2021 520 $aAbstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular processes regulation and potassium channels. Conclusions: Overall, this CNV-based GWAS study unravels potential candidate genes that may regulate performance traits in chickens. Our findings provide a foundation for future functional studies on the role of specific genes in regulating performance in chickens. Keywords: GWAS, Performance, CNVs, QTLs, qPCR 650 $aAnimal genetics 650 $aAnimal performance 650 $aGallus gallus 650 $aGenome-wide association study 650 $aQuantitative polymerase chain reaction 650 $aQuantitative trait loci 650 $aGallus Domesticus 650 $aGenética Animal 650 $aPerformance 653 $aCNVs 653 $aCopy number variations 653 $aDesempenho zootécnico 653 $aGWAS 653 $aQPCR 653 $aQTLs 700 1 $aSILVA, V. H. da 700 1 $aGOES, C. P. 700 1 $aMOREIRA, G. C. M. 700 1 $aGODOY, T. F. 700 1 $aIBELLI, A. M. G. 700 1 $aPEIXOTO, J. de O. 700 1 $aCANTAO, M. E. 700 1 $aLEDUR, M. C. 700 1 $aREZENDE, F. M. de 700 1 $aCOUTINHO, L. L. 773 $tBMC Genomics$gv. 22, n. 354, 2021.
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